USES: Relief and prevention of bronchospasm in bronchial asthma
Pack quantity: 100ML
Terbutaline is a selective beta2-adrenergic agonist recommended for the relief and prevention of bronchospasm in bronchial asthma and other bronchopulmonary disorders in which bronchospasm is a complicating factor.
For the management of uncomplicated premature labour.
Posology and method of administration
Use in bronchospasm
Bricanyl Syrup has a duration of action of 7 to 8 hours. The minimum recommended dosage interval is therefore 7 hours.
The starting dose should be 2 x 5ml spoonfuls 3 times in 24 hours. The dose may then be increased to 3 x 5ml spoonfuls 3 times in 24 hours if necessary to achieve adequate bronchodilation.
Elderly: Dosage as for Adults.
Children: The following dosage is recommended - 0.075mg (0.25ml)/kg body weight 3 times in a 24 hour period
Use in the management of premature labour.
Oral treatment should not be used initially in an attempt to arrest premature labour. After uterine contractions have been controlled by intravenous infusion of Bricanyl Injection, (see Bricanyl Injection Summary of Product Characteristics) or subcutaneous injections (0.25mg, 4 times in a 24 hour period for a few days) maintenance therapy can be continued with oral treatment (5mg, 3 times in a 24 hour period). Oral treatment may be continued for as long as the physician considers it desirable to prolong pregnancy.
Bricanyl Syrup should not be used as a tocolytic agent in patients with pre-existing ischaemic heart disease or those patients with significant risk factors for ischaemic heart disease.
Although Bricanyl Syrup is used in the management of uncomplicated premature labour, use in the following conditions is contra-indicated: -
â€¢ any condition of the mother or foetus in which prolongation of the pregnancy is hazardous, e.g. severe toxaemia, anti-partum haemorrhage, intra-uterine infection, severe pre-eclampsia, abruptio placentae, threatened abortion during the 1st and 2nd trimester, or cord compression.
Bricanyl Syrup should not be used in patients with a history of hypersensitivity to any of the ingredients.
Special warnings and precautions for use
As for all beta2-agonists caution should be observed in patients with thyrotoxicosis.
Cardiovascular effects may be seen with sympathomimetic drugs, including Bricanyl. There is some evidence from post-marketing data and published literature of myocardial ischaemia associated with beta agonists.
Due to the positive inotropic effect of beta2-agonists, these drugs should not be used in patients with hypertrophic cardiomyopathy.
Bricanyl should be used with caution in tocolysis and supervision of cardiorespiratory function, including ECG monitoring, should be considered. Treatment should be discontinued if signs of myocardial ischaemia (such as chest pain or ECG changes) develop. Bricanyl should not be used as a tocolytic agent in patients with significant risk factors for or pre-existing heart disease (see section 4.3, Contraindications).
During infusion treatment in pregnant women with beta2-stimulants in combination with corticosteroids a rare complication with a pathological picture resembling pulmonary oedema, has been reported.
Increased tendency to uterine bleeding has been reported in connection with Caesarean section. However, this can be effectively stopped by propranolol 1-2 mg injected intravenously.
Patients with underlying severe heart disease (e.g. ischaemic heart disease, arrhythmia or severe heart failure) who are receiving Bricanyl should be warned to seek medical advice if they experience chest pain or other symptoms of worsening heart disease.
Attention should be paid to assessment of symptoms such as dyspnoea and chest pain, as they may be of either respiratory or cardiac origin.
Due to the hyperglycaemic effects of beta2-agonists, additional blood glucose controls are recommended initially in diabetic patients.
Potentially serious hypokalaemia may result from beta2-agonist therapy. Particular caution is recommended in acute severe asthma as the associated risk may be augmented by hypoxia. The hypokalaemic effect may be potentiated by concomitant treatments (see section 4.5, Interactions). It is recommended that serum potassium levels are monitored in such situations.
If a previously effective dosage regimen no longer gives the same symptomatic relief, the patient should urgently seek further medical advice. Consideration should be given to the requirements for additional therapy (including increased dosages of anti-inflammatory medication). Severe exacerbations of asthma should be treated as an emergency in the usual manner.
Interaction with other medicinal products and other forms of interaction
Beta-blocking agents (including eye drops), especially the non-selective ones such as propranolol, may partially or totally inhibit the effect of beta-stimulants. Therefore Bricanyl preparations and non-selective beta-blockers should not normally be administered concurrently. Bricanyl should be used with caution in patients receiving other sympathomimetics.
Hypokalaemia may result from beta2-agonist therapy and may be potentiated by concomitant treatment with xanthine derivatives, corticosteroids and diuretics
Pregnancy and lactation
Although no teratogenic effects have been observed in animals or in patients, Bricanyl should only be administered with caution during the first trimester of pregnancy.
Terbutaline is secreted in breast milk, but effect on the infant is unlikely at therapeutic doses.
Transient hypoglycaemia has been reported in newborn preterm infants after maternal beta2-agonist treatment.
Asset Chemist is a registered pharmacy in the UK and is now the country\'s best value dedicated internet pharmacy. All of our content on this website is for information purposes only, and we recommend you use it as a support to the advice given to you by your healthcare providers. Please ensure you read all product packaging and labels prior to use. Please consult your doctor before using any new product. For more information view our Terms [&] Conditions.
We also provide a prescription service for you or your pet and delivery the medication direct to your door.
As an Online Pharmacy we strictly observe legal requirements in both our and your country. However, we recommend you check the importation regulations of your country to verify the laws of ordering online pharmaceuticals and over the counter medication from abroad. The buyer is responsible for determining and abiding by his/her country\'s importation regulations.
Please visit www.postoffice.co.uk/letters-parcels/mailing-guide/restricted-and-prohibited-goods