Epiduo Acne Gel 2.5% 45G

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Epiduo Acne Gel 2.5%

Epiduo is used for the treatment of acne.  Epiduo gel combines two active ingredients, Adapalene and Benzoyl peroxide

Epiduo Acne Gel 2.5% 45G

Epiduo should be applied to the entire acne affected areas once a day in the evening on a clean and dry skin.  A thin film of gel should be applied, with the fingertips, avoiding the eyes and lips
If irritation occurs, the patient should be directed to apply non-comedogenic moisturisers, to use the medication less frequently (e.g.  every other day), to suspend use temporarily, or to discontinue use altogether.
The duration of treatment should be determined by the Doctor on the basis of the clinical condition.  Early signs of clinical improvement usually appear after 1 to 4 weeks of treatment.
The safety and effectiveness of Epiduo have not been studied in children below 9 years of age.

What Epiduo is and what it is used for

Epiduo is used for the treatment of acne.
This gel combines two active ingredients, Adapalene and Benzoyl peroxide which work together but in different ways:
Adapalene belongs to a group of products known as retinoids and acts specifically on the skin processes that cause acne.
The other active ingredient, benzoyl peroxide, works as an antimicrobial agent and by softening and peeling the outer layer of the skin.

What you need to know before you use Epiduo

Do not use Epiduo:
if you are allergic to the active substances or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions when using Epiduo

You should not use Epiduo on areas where you have cuts, scrapes or eczema.
Make sure Epiduo does not get into your eyes, mouth or nostrils, and other very sensitive areas of the body.  Should this occur wash these areas immediately with plenty of warm water.
Avoid excessive exposure to sunlight and UV lamps.
Avoid getting Epiduo on your hair or coloured fabrics as it may bleach them and wash your hands thoroughly after you have used the medicine.
Talk to your doctor or pharmacist before using Epiduo.

Other medicines and Epiduo

Do not use other acne products (containing benzoyl peroxide and / or retinoids) at the same time as Epiduo.
Avoid using Epiduo at the same time as cosmetics that are irritant, drying or exfoliate the skin.

Pregnancy and breastfeeding and using Epiduo

Epiduo should not be used during pregnancy.
If you fall pregnant while taking Epiduo, the treatment must be discontinued and you should inform your doctor as soon as possible for a further follow-up.
Epiduo can be used during breastfeeding.  To avoid contact exposure of the infant, application of Epiduo to the chest should be avoided.
Ask your doctor or pharmacist for advice before taking any medicine.

Driving and using machines and using Epiduo

Not relevant.
Epiduo contains propylene glycol (E1520), an ingredient that may cause skin irritation.

3.  How to use Epiduo

Always use this medicine exactly as your doctor has told you.  Check with your doctor or pharmacist if you are not sure.
Epiduo is only intended for use in adults and adolescents aged 9 years and over.
Apply a thin film of gel evenly over acne affected areas once a day at bedtime, avoiding the eyes, lips and nostrils.  The skin should be clean and dry before application.  You should wash your hands thoroughly after you have used Epiduo.
Your doctor will tell you how long you will need to use Epiduo.
If you feel that the effect of Epiduo is too strong or too weak, talk to your doctor or pharmacist.
If you experience persistent irritation when applying Epiduo, contact your doctor.
You may be asked to apply a moisturizer, to use the gel less often or to stop for a short time, or to stop using the gel altogether.
If you use more Epiduo than you should:
If you use more Epiduo than you should on your skin, you will not get rid of your acne quicker, but your skin may become irritated and red.
Please contact your doctor or the hospital :
If you have used more Epiduo than you should.
if a child has accidentally taken this medicine.
If you accidentally swallow this medicine.
Your doctor will advise you on action to be taken.
If you forget to use Epiduo:
Do not apply a double dose to make up for forgotten individual doses.

Possible side effects of Epiduo

Like all medicines, this medicine can cause side effects, although not everybody gets them.
Epiduo may cause the following side effects at the site of application.
Common side effects (occur in less than 1 in 10 patients)
dry skin local skin rash (irritative contact dermatitis) burning sensation irritation of the skin
Uncommon side effects (occur in less than 1 in 100 patients)
itching of the skin (pruritus)
Unknown frequency of occurrence (cannot be estimated from the available data): swelling face, allergic contact reactions, swelling of the eyelid, tightness in the throat, pain of skin (stinging pain), blisters (vesicles).
If skin irritation appears after application of Epiduo, it is generally mild to moderate, with local signs as redness, dryness, scaling, burning and pain of skin (stinging pain), which peak during the first week and resolve without additional treatment.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist.  This includes any possible side effects not listed in this leaflet.  You can also report side effects directly via .  By reporting side effects you can help provide more information on the safety of this medicine.

5.How to store Epiduo

Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton.  The expiry date refers to the last day of that month.
Discard the tube or pump 6 months after first opening.
Do not store above 25°C.
Do not throw away any medicines via wastewater or household waste.
Ask your pharmacist how to throw away medicines you no longer use.  These measures will help protect the environment.
6. Contents of the pack and other information
What Epiduo contains
The active substances are: Adapalene and benzoyl peroxide.  One g of gel contains 1 mg (0.1 %) adapalene and 25 mg (2.5 %) benzoyl peroxide.
The other ingredients are: docusate sodium, disodium edetate, glycerin, poloxamer, propylene glycol (E1520), Simulgel 600 PHA (copolymer of acrylamide and sodium acryloyldimethyltaurate, isohexadecane, polysorbate 80, sorbitan oleate) and purified water.
What Epiduo looks like and contents of the pack
Epiduo is a white to very pale yellow opaque gel.
Epiduo is available in:
Plastic tubes containing 5g, 15g, 30g, 45g, 60g or 90g (not all pack sizes may be marketed).
Pumps containing 15 g, 30 g, 45 g or 60 g (not all pack sizes may be marketed).
Marketing Authorisation Holder and Manufacturer
Marketing Authorisation Holder
Galderma (UK) Ltd.
Meridien House
69-71 Clarendon Road
WD17 1DS

Epiduo Acne Gel 2.5% 45G

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